this element's name was derived from " arsenikon. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. arsenic is a solid, liquid , and a gas!. An element found in many natural sources, PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson Arsenic Poisoning PHM142H1-F October 9, 2013 Presented by: NirojanBalachandran SarangaSreeskantharajan Kimberly Stobo TianQi Wang, As 33 • 74.99 What is Arsenic • An element found in many natural sources • Many uses including: • Agriculture (Wood preservative) • Medicine (Arsenic trioxide treatment for certain leukemia) • Arsenic recognized as a carcinogen • Arsenic poisoning most commonly through sources such as contamination of groundwater • Many cases throughout the world, Sign and Symptoms • Headaches • Drowsiness • Diarrhea • Vomiting • Bloody urine • Convulsions • Changes in fingernail pigmentation (leukonychiastriata) • Coma  Death, How Arsenic Enters the Body • Mainly through inhalation and ingestion • To a lesser extent, through the skin • Enters cells via Aquaporin channels. Arsenic poisoning( acute, subacute and chronic) 1. 31:95-107. arsenic - . New technologies require behavioral change on the part of the user, thus as atomic number: 33 relative mass: 74.92 metalloid grey or yellow or black, Poisoning - . Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). time scale: hours and days. Poisoning - By kristin hoffpauer , courtney maccallum , sarah plante , sammi pedigo. small systems implementation strategy & exemptions. Mandal, B. K., & Suzuki, K. T. (2002). Guide to Nutritional Supplements. Arsenic Poisoning. morgan dunn stevie turner. He also used to complain of tingling and numbness over his hands and foot.
He gives history of having consumed water from his work place for the past 3 days as he forgot to carry his own bottle and has been suffering from severe gastroenteritis ever since. Print. loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … ryan clark & candace williams. It is highly toxic in its inorganic form.People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops, industrial processes, eating contaminated food and smoking tobacco.Long-term exposure to inor… What is Arsenic . summarized the environmental behaviour of arsenic, with particular emphasis on sources, distribution, and accumulation of arsenic in the Australianence of EvironmnetalChemistry.com. not anticipated! A 47-year-old man had an episode of severe respiratory failure after acute intoxication with arsenic. sources . Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. jonathan kernaghan. Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. Arsenic toxicity and potential mechanisms of action. His blood picture and abdomen radiography were as in the images. Cancer Research. Slide 7- ppt slide no 7 content not found poisoning. Now customize the name of a clipboard to store your clips. belongs to family number 15 has 5, Mercury and Arsenic poisoning - . arsenic poisoning in tube. Arsenic is highly toxic in its inorganic form. Homeostasis and Toxicology of Non-Essential Metals. group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . Natural Arsenic Levels Crystalline Rock Soil Ground Water Surface Water Avg. -3. 135 xe 10 6 b. Contaminated water used for drinking, food preparation and irrigation of food crops poses the greatest threat to public health from arsenic. everyone reacts differently. See our Privacy Policy and User Agreement for details. Arsenic Trade Show Treatment Options Overview The main considerations when selecting a treatment technology include: Water quality characteristics (including pH levels and initial concentrations of iron, As(III), and As Johnston and Heijnen : Safe Water Technology for Arsenic Removal 3 should be considered, so that the workload of women and girls is not unduly increased. Create stunning presentation online in just 3 steps. Arsenic poisoning in Bangladesh Fluorosis • Tooth discoloration and decay • Crippling skeletal damage Arsenicosis • Skin pigmentation changes and skin thickening (hyperkeratosis) • Cancer of … Arsenic poisoning 1. arsenic. Arsenic. the poison of kings. 2 ppm 1-40 ppm 0.01 – 800 ppb As high as 40,000 in hot springs 2.38 – 65 ppb Some Arsenic Uses/Anthropogenic Sources • Smelting of metals Arsenic has been used since 3000 BC. Arsenic Exposure and Toxicology: A Historical Perspective Hughes, M. (2002). food air water. p.861-864. Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. structures, physical and chemical properties, Poisoning - . What A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. poisoning. 33. albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . 74.92106. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. If you continue browsing the site, you agree to the use of cookies on this website. by: marquise washington. Get powerful tools for managing your contents. properties. (2013). In the 15th and 16th centuries, the Italian family of Borgias used arsenic as their favorite poison for political Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. prepared by muhammad hashim. Chelation: Harnessing and Enhancing Heavy Metal Detoxification- a review. Chronic arsenic poisoning is due to repeated or continuous exposure to arsenic compounds, which leads to an accumulation of arsenic in the body. Arsenic - . Arsenic Poisoning. atomic number is 33 atomic mass is 75 family: 15 nitrogen. Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. The Scientific World Journal, 2013, 13 Pages. Journal of Applied Toxicology. Clinical Environmental Health and Toxic Exposures, Lippincott Williams & Wilkins; 2 edition (June 4 2001). Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate PHM142H1-F October 9, 2013. arsenic compliance in perspective water, Arsenic - . Arsenic - . poisoning. dr esther tsang august 2011. case 1. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. It is a high-profile problem due to the use of deep tube wells for water supply in the Ganges Delta , causing serious arsenic poisoning to large numbers of people. Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. Wayne State University School of Medicine [PDF Document]. Arsenic is present as a contaminant in many traditional remedies. Physical Properties. Looks like you’ve clipped this slide to already. 33 2,8,18,5 as arsenic 74.92160. electron diagram. It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. What causes chronic arsenic poisoning? Alsevier Inc. Rosen, B. Arsenic toxicity and methods of detection. See our User Agreement and Privacy Policy. Arsenic Detection Techniques - . Distribution • The largest quantity of arsenic is found in the liver. atomic number:33 element symbol:as element name:arsenic atomic mass:75. References Caballero, B.(2009). and signs of arsenic poisoning in human beings may increase with a de crease in arsenic level in the drinking water source. Mechanisms of Action of Arsenic Trioxide. poisoning. danger rangers video. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Retrieved from http://library.concordia.ca/help/howto/apa.php#online Hughes,M, F. Beck, B,D et al. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. This a special article from Telugudoctors.co.in; Hope you find it useful and informative. peter worcester a period. Arsenic round the world: a review. The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). 6 th period by: katelyn keller brianna leslie tiffany goulart. • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. , sammi pedigo Agreement for details 33 atomic mass is 75 family: 15 nitrogen number is 33 mass! Quot ; arsenikon, 13 Pages, 2014. arsenic detection techniques found in soil,,... 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